Science + Technology

Many genetic diseases involve loss of function of a gene leading to less functional protein being made within cells.

This loss of function is what causes the imbalance in genetic disease. At Sharp we create small molecule drugs, the kind that can be taken as a pill. Our compounds restore the function of mutated proteins to correct the fundamental imbalance in each disease. With drugs that can treat a genetic disease at its core cause, diagnosis will be the first step on the path to better health.

Sharp has developed the patent-protected Disco(tm) discovery platform consisting of the CoreX™ biology, AlloChem™ chemistry and Mine™ computational technologies to discover drugs that selectively activate the protein that’s been altered by gene mutation.