SCIENCE + TECHNOLOGY

AlloChem™

Screening Libraries Enriched with Drug-Like Correctors

The AlloChem compound libraries are created using IP-protected computational methods to select compounds most likely to bind proteins allosterically, thus stabilizing and activating them. Based on extensive supercomputing-scale thermodynamic simulations and analysis of known allosteric binding compounds, the AlloChem libraries are enriched with compounds that can functionally activate proteins while still complying with the standard rules for drug-like small molecules.

These are not “virtual libraries,” but physical compounds that Sharp tests in its CoreX assays to identify small molecules that correct genetic defects in the cellular context.

While the compounds were selected computationally, the combination of the CoreX assays and the AlloChem libraries is an experimental discovery approach. While computational methods have advanced, the ultimate test of biological activity is in an experiment using cells from patients. Sharp starts with this ultimate test.